Construction of Meredith House, which was once the focal point of a large farm, was begun around 1760 by John Woolford. Enlarged and remodeled over the years, today it looks much as it did in the 1850's, after the dormers and Greek revival ornamentation had been added. The Society purchased the home in 1959, assisted by a generous contribution from Thomas Steele Nichols. It is one of a few Georgian style structures remaining in Cambridge, and the only historic home in the County maintained as a museum. Once known as La Grange, it was renamed, Meredith House in honor of Mr. Nichol's maternal grandfather and great-grandfather, who were landowners and farmers in the County. It was listed in the National Register of Historical Places in 1981.

The house is furnished with fine antiques, several portraits of early County residents, and other household items. On the second floor, there are two rooms of particular interest: the Children's Room, which features a collection of antique dolls and toys, and the Governors' Room, which exhibits memorabilia from the seven Maryland governors who have resided in the County.